Refinex in cosmetology. Efficacy, side effects of use, reviews of cosmetologists

Over time, signs of aging and facial wrinkles begin to appear on the skin. Withering becomes noticeable to everyone around. This fact is very frustrating for women. Refinex injections are used to correct the situation. According to the reviews of cosmetologists, they give a good anti-aging effect.

Before use, it is recommended to familiarize yourself with the action of the drug, contraindications and side effects from the procedure.

Chemical composition

The active component of Refinex is botulinum neurotoxin . Thanks to him, the drug has a pronounced muscle relaxant effect. Penetrating into the deeper layers of the skin, the substance affects the receptors that are on the surface membrane of neurons. As a result, mediator secretions cease to enter the synaptic cleft.

In 1 bottle of the product may contain 50 or 100 units of action of the active substance. Before use, it undergoes a phased cleansing procedure. As a result, botulinum toxin crystallizes, dissolves and is filtered again.

After processing, the component is mixed with:

  • sucrose;
  • dextran;
  • gelatin.
Refinex in cosmetology. Efficacy, side effects of use, reviews of cosmetologists
Dosage form of Refinex

The resulting composition is dried, frozen and sublimated. It turns out a powder called lyophilisate. It is intended for dissolution. The drug is hypoallergenic.


Refinex has an effect that determines the active component. Botulinum toxin is a powerful muscle relaxant. It reduces the tone of the muscles of the face. Blocking the activity of facial muscles prevents the occurrence of creases and folds on the skin. The effect occurs immediately after the drug enters the epidermis.

Stages of inhibition of neuromuscular impulse:

  1. Communication with receptors. Lasts for 30 minutes. Molecules of the active substance communicate with the receptors of glia and neurons, as well as terminals.
  2. Endocytosis . Membrane vesicles form. They are needed for external capture by epidermal cells. Bound butolotoxin penetrates into the fluid inside the cell.
  3. Acetylcholine release . Having reached the space inside the cell, the substance inhibits the synthesis of acetylcholine. It provides transmission of nerve impulses at the level of the neuromuscular synapse.

Refinex, reviews of cosmetologists about which help to evaluate the effect of the procedure, completely fixes the facial muscles. At the same time, facial expressions of a person remain natural. People around do not notice changes in it.

The drug fills folds and cracks. It is under the skin for 2-3 weeks. This time is enough to completely absorb into the layers of the epidermis. Sucrose and proteins are absorbed into the soft tissues. These components normalize skin metabolic processes, activating the natural regeneration of cells.

Refinex in cosmetology. Efficacy, side effects of use, reviews of cosmetologists

The muscles stop contracting and completely relax. Due to this, wrinkles are smoothed out at the injection site and skin tension passes. Deep folds become less noticeable, turgor rises.

People with increased activity of the facial muscles experience discomfort and cramping. The effect is aimed at eliminating visual flaws in the skin, creases and folds. The procedure fights wrinkles around the lips, eyes and forehead.

The purpose of the introduction of the substance are:

  • strabismus in a paralytic form;
  • pathology of the cervical muscles and its constant tension;
  • regular eyelid closure due to contraction of the circular ocular muscles;
  • nervous tick.

Expect a pronounced anti-aging effect with strong signs of aging is not worth it. Botulinum toxin for this skin condition has a weak effect.

Serious age-related changes require complex therapy. The active substance is also ineffective in loosening the collagen layer and dehydration of soft tissues.

Refinex in cosmetology. Efficacy, side effects of use, reviews of cosmetologistsThe result after applying Refinex, depending on the area of administration:

  1. Eyelids. Injections make the look more expressive and raise eyebrows. Contribute to smoothing wrinkles around the eyes and crow’s feet.
  2. Forehead . Horizontal folds disappear and the eyebrow line is restored. After the procedure, lifting of the upper part of the face is observed.
  3. The area between the eyebrows . Glance ceases to be gloomy and tired due to smoothing of a vertical fold.
  4. Mouth . Small wrinkles are removed, lips acquire a beautiful bend. The drug is rarely introduced into this area due to the high probability of complications.

A distinguishing feature of Refinex from other drugs of a similar effect is the infusion of a minimum dose of the finished solution. This feature has a positive effect on the well-being of the patient during the session and on the effect itself.

For comparison, facial expressions come to their natural state within 2-4 hours, when Botox injections can disrupt its mobility for 5-7 days after getting under the skin.


The procedure for introducing Refinex does not involve serious preparatory measures.

Some rules must be observed before use:

  1. 2-3 days before it is recommended to stop taking medications that affect the ability of blood to clot. It is important to abandon aminoglycoside, erythromycin and tetracycline antibiotics in order not to get an enhanced injection effect.
  2. 7 days before the session, it is necessary to exclude the use of alcoholic beverages and nicotine.
  3. For 2-3 days it is not recommended to visit saunas and baths, take a hot bath. You should also refrain from chemical peeling.

At the beginning of the session, the cosmetologist conducts a thorough examination of the patient’s skin and asks the necessary questions. A medical history will help you choose the right method of administering the drug. The doctor needs to find out if the person has allergic reactions and chronic diseases, how long the infection has been transmitted.

Refinex in cosmetology. Efficacy, side effects of use, reviews of cosmetologistsRefinex, reviews of cosmetologists talking about a pronounced result, is used in the following sequence:

  1. Cleansing . Remains of cosmetics, impurities and sebaceous secretions are removed from the surface of the face and neck. The skin is treated with an antiseptic.
  2. Inspection The specialist examines the face and determines the injection site and dosage. To do this, make active grimaces. In the process, it is possible to understand the characteristics of aging skin.
  3. Consent. The patient draws up a document that indicates his consent to the injection. Before that, it is recommended to check the quality certificate and expiration date of Refinex.
  4. Anesthesia . As anesthesia use cream “Emla”. The action of anesthetic begins after 20 minutes. after application.
  5. Cooking . The cosmetologist must open the package with the drug strictly in the presence of th
    e patient. The substance is diluted in the desired dosage.
  6. Introduction . At the marked points, the substance is introduced into the dermis and hypoderm by the classical method. To do this, use a special thin needle and an insulin syringe. The allowed volume of the substance in each muscle is 0 fluid ounce. It is unacceptable for the needle to enter small vessels and capillaries. If this still happened, immediately pull out the needle and continue the introduction of the drug into another area.
  7. Processing . At the end of the procedure, an antiseptic and a soothing cream are applied to the skin. To prevent puffiness, apply a cold compress.

Refinex in cosmetology. Efficacy, side effects of use, reviews of cosmetologistsFor some time after injections, it is impossible to strain the treated areas of the face. Otherwise, the drug is distributed unevenly in the tissues. Within 30 minutes the patient remains under the supervision of a specialist. During this time he gives recommendations for skin care in the coming days. The dosage of the substance is selected individually based on the location of wrinkles, their depth and quantity.

The average volume of Refinex depending on the problem area is presented in the table:

Processing area The amount of the drug, UNIT
Mouth corners 3-6
Chin and jaw 40-60
Nose 5-10
Outer corners of the eyes 5-15
Drooping eyelid 2-5
Eyebrow Wrinkle 10-25


The procedure, despite the safe operation, has several limitations. When planning injections using Refinex, it is recommended that you consult a specialist.

Active tuberculosis, renal failure, pathologies of the cardiovascular and respiratory system do not belong to strict contraindications. Each case of manifestation of such deviations is considered individually.

Refinex, reviews of cosmetologists about which can avoid the serious consequences of the introduction, is strictly contraindicated in:

  • myasthenia gravis;
  • individual intolerance to the substances that make up the composition;
  • Lambert-Eaton syndrome;
  • pregnancy
  • a high degree of myopia;
  • critical days;
  • under the age of 18;
  • breastfeeding;
  • damage to the skin;
  • infectious and inflammatory diseases on the skin;
  • exacerbation of chronic diseases;
  • feverish conditions; Refinex in cosmetology. Efficacy, side effects of use, reviews of cosmetologists
  • autoimmune diseases;
  • clotting problems;
  • violations in the endocrine system;
  • oncology;
  • diabetes mellitus.

Side effects

It is necessary to carefully select the dosage. Exceeding it contributes to the development of serious complications. The occurrence of side effects after Refinex is due to the high toxicity and other features of botulinum toxin. Counterfeiting can also be harmful.

Refinex before use requires a careful study of the list of side effects, as well as reviews of patients and cosmetologists. The doctor must allow the person to the procedure. Only a specialist can assess the possible risks of the drug.

Complications after the procedure include:

  • asymmetry of the face with the wrong technology of drug administration;
  • bruising and swelling at the puncture site;
  • muscle weakness;
  • dizziness;
  • incomplete closure or drooping eyelids;
  • violation of natural facial expressions;
  • headache and migraine;
  • renal and intestinal colic;
  • fatigue and depression;
  • temperature increase;
  • ptosis of the skin;
  • chills;
  • diarrhea;
  • vomiting
  • pain in the injection area;
  • dry mucous membranes and burning eyes.

Refinex in cosmetology. Efficacy, side effects of use, reviews of cosmetologistsViolation of the sterility of the conditions of the procedure leads to infection of the skin. Complications after the administration of Refinex pass independently after 2-3 days, do not require intervention. In 10% of cases, unpleasant symptoms can occur as long as the substance acts. If unpleasant symptoms persist for more than 3 days, seek medical attention.

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Opinions of doctors and cosmetologists

Reviews of cosmetologists about Refinexer are different. Many doctors are skeptical about the drug. Distrust is due to the lack of information about the manufacturer. If the data is presented, then access to it is closed. Specialists complain about fakes that are common.

An experienced cosmetologist, Svetlana Sinitsyna, notes that the substance is of high quality. It is highly effective in combating the signs of aging. The action is similar to botox, because the composition contains the same component – purified botulinum toxin in stages.

Use of the substance rarely leads to allergies. In order not to lead to complications after the session, it is important to clearly calculate the dosage and correctly perform the injection.

The doctor is embarrassed that the specified information about the manufacturers cannot be verified. About the com
pany that is mentioned, data could not be found. To protect himself from a fake substance, the doctor recommends buying the drug from a trusted supplier.

When to expect an effect

Within 2-3 hours after the session, the result becomes visible. It will intensify over several days. After a week, they evaluate the effect obtained. If required, repeat the procedure. The effect lasts from 6 to 8 months.

Refinex in cosmetology. Efficacy, side effects of use, reviews of cosmetologistsCases were recorded when patients did not notice any changes after the procedure. Experts explain that the lack of effect is associated with a protective reaction of the body to the active component. Active production of antibodies to botulinum toxin is found in only 4% of people.

Refinex is a new generation drug in cosmetology, which is popular among modern women who care about beauty and health.

According to reviews, its use gives a high result in the fight against signs of aging. The effect is pronounced and lasts a long time. The use of the drug has a number of indications and serious side effects. Therefore, before the procedure, it is important to consult with your doctor. Injections should be performed only by a highly qualified cosmetologist.

Video on the topic: the mechanism of action of the drug Refinex

The mechanism and speed of action of the drug Refinex:

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